Consolidated Bioprocessing (CBP) for High Efficiency Fermentation

Mascoma’s CBP Delivers Value to Producers

For biofuel and biochemical producers consistently achieving the highest rates, titers and yields of products possible is an imperative.  Moving down the production cost curve for conversion of starch, sugar and cellulosic materials in this multi-billion dollar market requires optimal performance of industrial biocatalysts.  Traditional processes use enzymes to break down complex sugars to simple sugars, and yeast or other microorganisms to convert these simple sugars to products like ethanol.  Mascoma’s CBP combines and optimizes these two processes to deliver value to producers:

  • Enzyme Production: Specially designed and engineered yeasts, such as TransFerm, produce the required enzymes to break down complex sugars during fermentation, saving costs related to producing, stabilizing and shipping enzyme additives, and increasing yields by cost effectively breaking down more complex sugars.
  • Fermentation: Engineered yeasts which can ferment xylose, have broader substrate ranges than wild type strains to significantly increase fermentation yields on complex substrates.  Optimization of metabolic pathways in strains like TransFerm Yield+, can reduce the formation of byproducts such as glycerol, significantly increasing yield.

CBP from Novel Concept to Proven Industrial Application

CBP combines and optimizes biological steps during production. The concept has been studied extensively including the following papers:

CBP has been identified as a breakthrough technology. It’s potential is achieved by modifying the genetic code of industrial yeast strains giving these traditional workhorses new properties.  Stable, optimized, genetic elements are introduced to enable new capabilities, and the new strains are rigorously benchmarked against standard strains to prove the value.

If you are searching for reliable yield increasing solutions for your process, please contact us.